Pemetrexed disodium heptahydrate, a chemical compound is L-glutamic acid, N-[4 - [2 - (2-amino-4 0.7-dihydro-4-oxo-1H pyrrolo [2,3-d] pyrimidin-5-Joel ) ethyl] benzoyl] -, disodium salt, heptahydrate. It is white with molecular formula C20H19N5Na2O6 • 7H2O and molecular weight 597.49. Pemetrexed structural formula like this:
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Pemetrexed, which is marketed under the trade name Alimta, a chemotherapy drug approved by FDA for the
treatment of malignant pleural mesothelioma. French researchers reported in the European Lung Cancer Conference-2 that the first phase of clinical trials suggest that Pemetrexed also tolerated quite well by using high doses combined with concurrent radiation therapy to improve effectiveness as a treatment of lung cancer.
The first experiment was conducted using Pemetrexed with cisplatin chemotherapy and radiotherapy in nine patients with stage III non-small-cell lung cancer. A tenth of patients excluded because of disease progression. Seven of the nine remaining patients who completed all four cycles of chemotherapy, and eight of them completed the radiation therapy.
One patient receiving the highest dose of pemetrexed grade 4 experienced septic shock, dose-limit show toxicity. But overall, pemetrexed tolerated well enough to increase the likelihood of killing cancer cells.
Reference
First trial of pemetrexed with radiation and Chemo in lung cancer shows promising results - physorg European Society for Medical Oncology
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