1 What Are The Four Stages of Mesothelioma Cancer?

One rare form of cancer is called Mesothelioma, a malignant tumor in the mesothelial tissues of the lungs and the abdomen, arising from the inhalation of asbestos.

Its rarity is one of the reasons why a lot of people are not aware of this kind of fatal disease. In fact, many people die of Mesothelioma undiagnosed. Although there is now a growing awareness of the hazards of asbestos to health, still many have not heard of Mesothelioma and thus, have not understood its nature, cause, signs and treatment. Even some physicians find it hard to detect
Mesothelioma because its symptoms are akin to other diseases like lung cancer and pneumonia. Furthermore, it takes decades for a patient who was exposed to asbestos to develop Mesothelioma — fifty years, at most.

Being unaware of Mesothelioma poses higher risks since it deters diagnosis and treatment. A person undergoing treatment must know the different stages of the cancer or the extent of the disease. Chances of recovering from Mesothelioma and the kind of treatment depend on the stage of the illness. There are basically two staging systems used for Pleural Mesothelioma (lungs): TNM system and Brighan system. These staging systems are also used in other kinds of cancers; however, the first is commonly used. There is no established method in determining the stage of the Peritoneal Mesothelioma cancer (abdominal) so the TNM system is used.

There are three variables in the TNM system: tumor, lymph nodes and metastasis. In the earliest stage of Mesothelioma, stage I, the malignant Mesothelioma cells start to grow and multiply only one layer of the pleura.
The pleura is the membrane that encloses the lungs and lines the wall of the chest cavity. However, there are some instances wherein the pericardium (membrane that covers the heart) and diaphragm cover are already affected. In this case, the cancer patient is still in stage I Mesothelioma.

In the second stage, the two layers of the pleura are already affected by Mesothelioma. Take note, however, that in this stage, only one side of the body is affected. Normally, the pleura produces only small amount of lubricating fluid that allows easy expanding and contracting of the lungs. The excess fluid is absorbed by the blood and the lymph vessels so there’s a balance between the amount of fluid produced and removed. During the second stage Mesothelioma, fluid starts to build up between the membrane of the lungs and the membrane of the chest wall, resulting to pleural effusion. The increase in the volume of fluid produced causes shortness of breath and chest pain. Other Mesothelioma cancer patients experience dry and persistent cough. Diagnosis of the pleural effusion is achieved through a chest x-ray.

Stage III Mesothelioma means that the malignant cells have already spread to the chest wall, esophagus and the lymph nodes on one part of the chest. The patient may suffer severe pain near the parts affected. When not treated immediately or when the Mesothelioma patient doesn’t respond well to medication, the cancer may advance to the fourth stage. The fourth stage Mesothelioma is formidable since at this stage the Mesothelioma cells have penetrated into the bloodstream and other organs in the body like the liver, the bones and the brain. The lymph nodes on the other side of the chest may also be affected by Mesothelioma in stage IV.

Brighan staging system, on the other hand, determines whether the Mesothelioma can be surgically removed or not and whether the lymph nodes are affected or not. In stage I Mesothelioma, the lymph nodes are not yet affected and the patient can still recover through surgery. In stage II, surgery can still be executed but some lymph nodes have already been infiltrated by the cancer cells. In stage III, the heart and chest wall are already affected; thus, surgery is no longer advisable. The lymph nodes in
this stage, however, may or may not be affected. In the final stage, stage IV Mesothelioma, cancer cells have already gone to the bloodstream and other parts of the body like the heart, brain, bone and liver. In most cases, a patient who has reached stage IV Mesothelioma only has four to twenty-four months to live.

Mesothelioma Asbestos Cancer
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0 Asbestos on Human Health Hazards

In industrialized countries, lung cancer is one of the main causes of death from all cancer deaths. Most lung cancer suffered by those aged 40 to 70 years. Smoking is one risk factor in lung cancer and 80% of cases of lung cancer in smokers. Exposure to certain chemicals in the workplace is also clearly associated with development of lung cancer.

Tuberculosis incidence rate was increased in workers exposed to some form of nickel, chromium, and asbestos. Asbestos is widely used as roof-making materials (tiles) and insulation, asbestos cement, brake linings, electrical devices, and fire-resistant materials and packaging materials. Asbestos is the common name of a group of natural silicates which will split into flexible fibers. Exposure can come from natural sources and industrial usage. There are two types of fiber flcksibel, krisotil and krosidolit. Krisotil (3MgO.2SiO, .2 H2O) is a very important species in world trade and 90% of it consists of asbestos.
Krosidolit (blue asbestos), composed of rod-shaped fibers are short and more dangerous than krisotil fibers.

System disease caused by exposure to asbestos exposure include asbestosis, lung cancer, and mesotelioma. Other cancers associated with exposure to asbestos is a cancer of the larynx, esophagus, stomach, colon-rectum, and possibly pancreatic cancer.

Asbestosis is pulmonary fibrosis that developed slowly due to inhaling asbestos dust due to high concentration or long exposure. Severity depends on the time span between awitan (initial) exposure and its intensity, and asbestosis is often associated with advanced lung cancer, especially among smokers.

Mesotelioma is a rare type of pleural cancer. Increasing incidence mesotelioma associated with inhalation of asbestos fibers in the working environment. Although initially symptoms slightly, mesotelioma curable if successfully diagnosed. The time between exposure to asbestos and the occurrence of the first signs of tumors ranging from 20 to 50 years, specializing mesotelioma. The increase in incidence rate mesotelioma also seen in the population who, although not exposed in occupational, household living with asbestos workers or live around a strong source of asbestos emissions Although asbestos is no longer used as an insulator, this substance is still in the spotlight because of bahaya coming from the building sekatnya use of asbestos.
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2 Mesothelioma Cancer, Asbestos and Industrial

In industrialized countries, lung cancer is one of the main causes of death from all cancer deaths. Most lung cancer suffered by those aged 40 to 70 years. Smoking is one risk factor in lung cancer and 80% of cases of lung cancer in smokers. Exposure to certain chemicals in the workplace is also clearly associated with development of lung cancer.

Tuberculosis incidence rate was increased in workers exposed to some form of nickel, chromium, and asbestos. Asbestos is widely used in industry. Importance of usability in the industry is asbestos cement sheets and pipes, insulation materials, compounds for soldering, and tiles for floors and ceilings. Indoor air contamination, especially in schools, has become a major concern in many countries. Some countries have even banned the use of asbestos in constructing dantatau prohibit demolition of buildings containing a compound that.

System disease caused by exposure to asbestos exposure include asbestosis, lung cancer, and mesotelioma. Other cancers

associated with exposure to asbestos is a cancer of the larynx, esophagus, stomach, colon-rectum, and possibly pancreatic cancer.

Asbestosis is pulmonary fibrosis that developed slowly due to inhaling asbestos dust due to high concentration or long exposure. Severity depends on the time span between awitan (initial) exposure and its intensity, and asbestosis is often associated with advanced lung cancer, especially among smokers.

Mesotelioma is a rare type of pleural cancer. Increasing incidence mesotelioma associated with inhalation of asbestos fibers in the working environment. Although initially symptoms slightly, mesotelioma curable if successfully diagnosed. The time between exposure to asbestos and the occurrence of the first signs of tumors ranging from 20 to 50 years, specializing mesotelioma. The increase in incidence rate mesotelioma also seen in the population who, although not exposed in occupational, household living with asbestos workers or live around the source of asbestos emissions. Although asbestos is no longer used as an insulator, this substance is still in the spotlight because of the danger that comes from building sekatnya using asbestos.
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1 Plumber (Plumber) high-risk suffering from Mesothelioma


Plumber (Plumber) is the industrial workers most at risk for the deadly cancer mesothelioma. That's the findings of an insurance industry study recently conducted in England.

In a report prepared by the National Claims, finding that the former plumbers or plumbers, and electrical, construction workers and auto mechanics, have a much higher possibility of exposed asbestos-related cancers than people who work in other industries. This is a finding that is supported by CDC researchers in the United States which found the number of mesothelioma deaths among plumbers and predict these events can continue to increase over 40 years.
Mesothelioma Plumber Cancer
Asbestos is an insulating material widely used in industries around the world until the 1980s. This is primarily about pipe resilience to temperature extremes and corrosion. Although no longer used in new construction - and even been banned in more than 40 countries (though not in the United States) - Asbestos is still around water pipes, in pipe fittings and water heating filament millions of old homes and commercial buildings. Plumbers who do cutting pipes, repairing or replacing pipes, can release toxic fibers which is a forerunner to the emergence of mesothelioma, lung cancer, asbestosis and other diseases.

The report warned that the UK insurance and ex-plumber plumbers, mesothelioma is a very dangerous disease because it tends to develop slowly, with symptoms that can mimic other conditions, diagnosis of mesothelioma is initially very small possibility of this disease was found to gradually develop in the future day. According to the report "The symptoms of asbestosis is often only emerge 15 to 20 years after initial exposure to asbestos. Symptoms begin gradually, and may become more visible for several years. Common symptoms are shortness of breath (initially after physical activity, but eventually also while resting), coughing, wheezing, and chest pain. "

At the same time, 'Daily Telegraph' in England reported expenses incurred by a former plumber who was diagnosed with mesotelioma in hospitals around 175 000 pounds.
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0 Types of Cancer Treatment Malignant Mesothelioma

Treatment for malignant mesothelioma has not been found, but the people affected by this disease still prefer to undergo treatment with a mixture of methods or participate in various clinical trials. Types of mesothelioma treatment techniques are regularly performed with the surgical procedure, drug therapy, and radiation therapy.

Malignant Mesothelioma Cancer Symptoms

Although these treatments are most often found, you can find other treatment options are now increasing in popularity. Several treatment options, which are gene therapy, immunotherapy, and photodynamic therapy.

The different surgical procedures performed on patients with malignant mesothelioma there are three types of palliative surgical procedures, surgical procedures for diagnostic, curative surgical procedure. Palliative surgery aimed at reducing the symptoms and eliminate all cancer cells. Even so, the type of operation is not very advisable.

Destination curative surgery is to remove as much mesothelioma cancer, hoping this type of therapy can completely cure people. Curative surgery is usually followed by chemotherapy or radiation therapy.

Differences in pleural mesothelioma and peritoneal mesothelioma

Treatment Mesothelioma
Diagnostic surgical approach intended to do with finding facts or not there is cancer in patients. This procedure is an addition that can help identify where the location of cancer, if found, the diagnosis of mesothelioma is usually still in the form of non-invasiv.

Chemotherapy drugs given intravenously with the aim to destroy cancerous tissue. Mesothelioma cancer cells grow very fast and delivery of chemotherapy would be more effective if given promptly.

Radiation therapy was done by comparing drug therapies, which aim to destroy cancerous tissue and limit the spread of cancer cells much as possible. This mode is also called "ionizing radiation" and is usually used after surgery. The mechanism works the same with palliative care that also aimed to eliminate pain caused by the disease.


Mesothelioma Prognosis

Photodynamic therapy is usually used if the cancer malignant mesothelioma is still small and less effective for metastasis.Terapi photodynamic cancer therapy requires intravenous medication that will kill the cancer cells will be susceptible to a particular result.

This gene treatment is still experimental d? N need people who will be infected by an h? virus that would make a change genetically. The virus entered the mesothelioma cancer cells that cause the production of proteins. Some time after the virus infects people who have changed genetically, will be given chemotherapy drugs that do not damage normal cells, but is able to kill cancer cells.

Immunotherapy is given notice of the individual body's immune system tries to destroy cancer cells. With the Active Immunotherapy of individuals, malignant mesothelioma cells would be removed which is then used to produce vaccines. The person who injected the vaccine, will have an immune system capable of recognizing "malignant mesothelioma cell vaccine" as a hazardous substance, so that the cancer cell itself is known as a dangerous substance.

Reference
Submission Press
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0 Drug-Radiation Combination Therapy for Mesothelioma Cancer

Pemetrexed disodium heptahydrate, a chemical compound is L-glutamic acid, N-[4 - [2 - (2-amino-4 0.7-dihydro-4-oxo-1H pyrrolo [2,3-d] pyrimidin-5-Joel ) ethyl] benzoyl] -, disodium salt, heptahydrate. It is white with molecular formula C20H19N5Na2O6 • 7H2O and molecular weight 597.49. Pemetrexed structural formula like this:
Structure For
Pemetrexed, which is marketed under the trade name Alimta, a chemotherapy drug approved by FDA for the treatment of malignant pleural mesothelioma. French researchers reported in the European Lung Cancer Conference-2 that the first phase of clinical trials suggest that Pemetrexed also tolerated quite well by using high doses combined with concurrent radiation therapy to improve effectiveness as a treatment of lung cancer.

The first experiment was conducted using Pemetrexed with cisplatin chemotherapy and radiotherapy in nine patients with stage III non-small-cell lung cancer. A tenth of patients excluded because of disease progression. Seven of the nine remaining patients who completed all four cycles of chemotherapy, and eight of them completed the radiation therapy.

One patient receiving the highest dose of pemetrexed grade 4 experienced septic shock, dose-limit show toxicity. But overall, pemetrexed tolerated well enough to increase the likelihood of killing cancer cells.

Reference
First trial of pemetrexed with radiation and Chemo in lung cancer shows promising results - physorg European Society for Medical Oncology
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0 Mesothelioma Chemotherapy: Comparison of cisplatin and carboplatin

Lung Can
A mesothelioma articles recently published in scientific journals Lung Cancer that investigates the benefits and costs Pemetrexed combined with cisplatin and carboplatin chemotherapy and Pemetrexed for mesothelioma.

PA Photos Mesothelioma Exposure AsbesKemoterapi combination cisplatin and Pemetrexed is one of several choices of chemotherapy that has proven quite successful in the treatment of patients with malignant pleural mesothelioma / malignant pleural mesothelioma (MPM), but this combination can be very toxic to the body. There is no treatment and treatment for malignant mesothelioma cancer without undesirable side effects.

In these journals the researchers noted that "there are two phases of the study in phase III randomized to the prognosis of mesothelioma showed benefit with the use of antifolates such as raltitrexed or Pemetrexed, when combined with cisplatin. The study has demonstrated an absolute improvement in overall survival of 2.6 and an average of 2.8 months, compared with single treatment for cisplatin. This makes a lot of institutions use Pemetrexed and cisplatin chemotherapy as the standard palliative treatment for malignant pleural mesothelioma. "

Unfortunately, the combination of cisplatin and Pemetrexed produce unwanted toxic effects and it encourages researchers to study other chemotherapy drugs to be combined with Pemetrexed. The researchers said, "Recently, two phase II trials have evaluated the efficacy of carboplatin and will Pemetrexed in MPM. Both studies showed overall response rate of 18.6 and 25%, with a survival rate average of 12.7 and 14 months. As a continuation of these results, we conducted a retrospective analysis in patients with MPM who were treated with carboplatin and Pemetrexed in our institution. "

In an effort to find a combination of chemotherapy mesothelioma with minimal toxicity and side effects, the researchers investigated further by replacing cisplatin with carboplatin when paired with Pemetrexed. Using a retrospective approach, researchers evaluated 49 cases of malignant pleural mesothelioma with a combination of carboplatin and Pemetrexed and compare the results with the data given cisplatin combination chemotherapy with Pemetrexed.

Level of disease control (known in the absence of signs of progressive mesothelioma through CT scan) for patients is 69 percent, and partial response and stable disease percentage of 28 percent and 41 percent. Clinical improvement is shown in figure 69 percent, the majority of patients reported increased profits after two cycles of chemotherapy. Toxicity is generally low and better than the toxicity of cisplatin with Pemetrexed.

The average time of treatment failure was 4.6 months. The average overall survival in this study is 14 months, compared with cisplatin-pemetrexed for 12.1 months. Researchers argued, "In conclusion, our data show the combination carboplatin and Pemetrexed may be an option in the treatment of mesothelioma, particularly in patients who experience problems with the use of cisplatin."

Tags: Medical Articles, Articles Mesothelioma, Mesothelioma Chemotherapy, malignant pleural Mesothelioma, Mesothelioma, Chemotherapy drugs carboplatin, cisplatin chemotherapy drugs, chemotherapy, phase of chemotherapy, cancer chemotherapy, chemotherapy cycle, how to make poison
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